Some highly sterically hindered organosilicon compounds

Chiral phosphine-phosphoramidite ligands for highly efficient Ir-catalyzed asymmetric hydrogenation of sterically hindered N-arylimines.

A mild and general iridium-catalyzed, highly enantioselective hydrogenation of sterically hindered N-arylimines with a new H(8)-BINOL-derived phosphine-phosphoramidite ligand has been developed. The present catalytic system features high turnover numbers (up to 100000) and good to perfect enantioselectivities (up to 99% ee) for the hydrogenation of a variety of sterically hindered N-arylimines.

Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds.

The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.

BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS FACULTY OF CHEMICAL AND BIOENGINEERING GEORGE OLAH DOCTORAL SCHOOL Synthesis, characterization, and potential application of some organosilicon compounds

Extremely bulky secondary phosphinoamines as substituents for sterically hindered aminosilanes.

The synthesis of a series of extremely bulky secondary amines with a phosphine function, Ar(†)(PR2)NH (Ar(†) = C6H2{C(H)Ph2}2Pr(i)-2,6,4; R = Ph, NEt2, NPr(i)2) is described. Deprotonation with either n-BuLi or KH yields the respective alkali metal amides in some cases. Their reaction with the chlorosilanes SiCl4, HSiCl3, Cl2SiPh2, Cl3Si-SiCl3 and Si5Cl10 allows access to monomeric molecular co...

Regio- and stereoselective functionalization of electron-deficient alkenes by organosilicon compounds via photoinduced electron transfer*

Regioand stereoselective photoallylation of electron-deficient alkenes by use of allylic silanes via photoinduced electron transfer has been described. Similar photoinduced functionalization reactions such as arylmethylation, alkylation, and silylation can be achieved by using a variety of organosilicon compounds. These photoreactions proceed via radical cations of organosilicon compounds and r...